Pair Name	Sulforaphane, PP242
Disease Info	[ICD-11: 2B70]	Esophageal cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Down-regulation	Phosphorylation	AKT1S1	hsa84335
	Up-regulation	Expression	BAX	hsa581
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Phosphorylation	RICTOR	hsa253260
	Down-regulation	Phosphorylation	RPS6KB1	hsa6198
In Vitro Model	Eca-109	Esophageal squamous cell carcinoma	Homo sapiens (Human)	CVCL_6898
	EC9706	Esophageal squamous cell carcinoma	Homo sapiens (Human)	CVCL_E307
Result	Our findings demonstrate that PP242 enhances the anti-tumor activity of SFN by blocking SFN-induced activation of Akt/mTOR pathway in ESCC, which provides a rationale for treating ESCC using SFN combined with Akt/mTOR pathway inhibitors.